Variation in actual relationship among descendants of inbred individuals

In previous analyses, the variation in actual, or realized, relationship has been derived as a function of map length of chromosomes and type of relationship, the variation being greater the shorter the total chromosome length and the coefficient of variation being greater the more distant the relationship. Here, the results are extended to allow for the relatives' ancestor being inbred. Inbreeding of a parent reduces variation in actual relationship among its offspring, by an amount that depends on the inbreeding level and the type of mating that led to that level. For descendants of full-sibs, the variation is reduced in later generations, but for descendants of half-sibs, it is increased

Development of reclaimed potable water quality criteria

In order to minimize launch requirements necessary to meet the demands of long-term spaceflight, NASA will reuse water reclaimed from various on-board sources including urine, feces, wash water and humidity condensate. Development of reclamation systems requires the promulgation of water quality standards for potable reuse of the reclaimed water. Existing standards for domestic U.S. potable water consumption were developed, but do not consider the peculiar problems associated with the potable reuse of recycled water. An effort was made to: (1) define a protocol by which comprehensive reclaimed water potability/palatability criteria can be established and updated; and (2) continue the effort to characterize the organic content of reclaimed water in the Regenerative Life Support Evaluation

Empirical source noise prediction method with application to subsonic coaxial jet mixing noise

A general empirical method, developed for source noise predictions, uses tensor splines to represent the dependence of the acoustic field on frequency and direction and Taylor's series to represent the dependence on source state parameters. The method is applied to prediction of mixing noise from subsonic circular and coaxial jets. A noise data base of 1/3-octave-band sound pressure levels (SPL's) from 540 tests was gathered from three countries: United States, United Kingdom, and France. The SPL's depend on seven variables: frequency, polar direction angle, and five source state parameters: inner and outer nozzle pressure ratios, inner and outer stream total temperatures, and nozzle area ratio. A least-squares seven-dimensional curve fit defines a table of constants which is used for the prediction method. The resulting prediction has a mean error of 0 dB and a standard deviation of 1.2 dB. The prediction method is used to search for a coaxial jet which has the greatest coaxial noise benefit as compared with an equivalent single jet. It is found that benefits of about 6 dB are possible

Pilot dynamic response to sudden flight control system failures and implications for design

Pilot dynamic response to sudden flight control system failure

Evolution and diversity of secretome genes in the apicomplexan parasite Theileria annulata

<b>BACKGROUND</b>: Little is known about how apicomplexan parasites have evolved to infect different host species and cell types. Theileria annulata and Theileria parva invade and transform bovine leukocytes but each species favours a different host cell lineage. Parasite-encoded proteins secreted from the intracellular macroschizont stage within the leukocyte represent a critical interface between host and pathogen systems. Genome sequencing has revealed that several Theileria-specific gene families encoding secreted proteins are positively selected at the inter-species level, indicating diversification between the species. We extend this analysis to the intra-species level, focusing on allelic diversity of two major secretome families. These families represent a well-characterised group of genes implicated in control of the host cell phenotype and a gene family of unknown function. To gain further insight into their evolution and function, this study investigates whether representative genes of these two families are diversifying or constrained within the T. annulata population. <b>RESULTS</b>: Strong evidence is provided that the sub-telomerically encoded SVSP family and the host-nucleus targeted TashAT family have evolved under contrasting pressures within natural T. annulata populations. SVSP genes were found to possess atypical codon usage and be evolving neutrally, with high levels of nucleotide substitutions and multiple indels. No evidence of geographical sub-structuring of allelic sequences was found. In contrast, TashAT family genes, implicated in control of host cell gene expression, are strongly conserved at the protein level and geographically sub-structured allelic sequences were identified among Tunisian and Turkish isolates. Although different copy numbers of DNA binding motifs were identified in alleles of TashAT proteins, motif periodicity was strongly maintained, implying conserved functional activity of these sites. <b>CONCLUSIONS</b>: This analysis provides evidence that two distinct secretome genes families have evolved under contrasting selective pressures. The data supports current hypotheses regarding the biological role of TashAT family proteins in the management of host cell phenotype that may have evolved to allow adaptation of T. annulata to a specific host cell lineage. We provide new evidence of extensive allelic diversity in representative members of the enigmatic SVSP gene family, which supports a putative role for the encoded products in subversion of the host immune response

Differential expression of microRNAs in bovine papillomavirus type 1 transformed equine cells

Bovine papillomavirus (BPV) types 1 and 2 play an important role in the pathogenesis of equine sarcoids (ES), the most common cutaneous tumour affecting horses. MicroRNAs (miRNAs), small non-coding RNAs that regulate essential biological and cellular processes, have been found dysregulated in a wide range of tumours. The aim of this study was to identify miRNAs associated with ES. Differential expression of miRNAs was assessed in control equine fibroblasts (EqPalFs) and EqPalFs transformed with the BPV-1 genome (S6-2 cells). Using a commercially available miRNA microarray, 492 mature miRNAs were interrogated. In total, 206 mature miRNAs were differentially expressed in EqPalFs compared with S6-2 cells. Aberrant expression of these miRNAs in S6-2 cells can be attributed to the presence of BPV-1 genomes. Furthermore, we confirm the presence of 124 miRNAs previously computationally predicted in the horse. Our data supports the involvement of miRNAs in the pathogenesis of ES

Tabulation and summary of thermodynamic effects data for developed cavitation on ogive-nosed bodies

Thermodynamic effects data for developed cavitation on zero and quarter caliber ogives in Freon 113 and water are tabulated and summarized. These data include temperature depression (delta T), flow coefficient (C sub Q), and various geometrical characteristics of the cavity. For the delta T tests, the free-stream temperature varied from 35 C to 95 C in Freon 113 and from 60 C to 125 C in water for a velocity range of 19.5 m/sec to 36.6 m/sec. Two correlations of the delta T data by the entrainment method are presented. These correlations involve different combinations of the Nusselt, Reynolds, Froude, Weber, and Peclet numbers and dimensionless cavity length

Conversion of the Community Unit School District Number One 1978-79 Chart of Accounts to the Chart of Accounts in the Illinois Program Accounting Manual

Section 2-3.27 of the School Code of Illinois requires the State Superintendent of Education to formulate and approve forms, procedures, and regulations for school districts in proper accounting of all receipts and disbursements; and to publish and keep current manuals, in loose-leaf form, relative to budgetary and accounting procedures. At the present time the state has issued two accounting guidelines, the Illinois Financial Accounting Manual and the Illinois Program Accounting Manual. Community Unit School District Number One is currently using the chart of accounts from the Illinois Financial Accounting Manual for Local School Systems, Circular Series A, Number 246, revised January, 1972. This field study was to change the present Community Unit School District Number One 1978-79 budget account numbers to the account numbers used in the Illinois Program Accounting Manual for Local Education Agencies dated 1976. The present bookkeeping system of Community Unit School District Number One is on a computer. A printout of the chart of accounts was requested for use. This is a listing of the account numbers presently utilized by the district by fund, description and numerical order. Reference was made to the Illinois Program Accounting Manual for Local Education Agencies for the new account numbers and description for each of the account numbers used by the district. Then, the new account numbers were recorded beside previously used account numbers. This process was used for all funds. The number of funds maintained by Community Unit School District Number One is six (6). These six funds were created when a tax levy was authorized by the Board of Education for a given purpose. The following funds are those used by Community Unit School District Number One: 1--Educational Fund 2--Operations, Building, Maintenance Fund 3--Bond and Interest Fund 4--Transportation Fund 5--Municipal Retirement Fund 7--Working Cash Fund The writer selected six of the eleven classification groups outlined in the manual. These six classification groups are referred to as dimensions, which are used to describe expenditure transactions. The dimensions presented below are the ones to be used by the school district: 1--Fund 2--Function 3--Object 4--Source of Funds 5--Operational Unit 6--Subject Matter Area The writer would recommend that any school district that is investigating changes in its accounting procedures should seek counsel from the Illinois Office of Education. This will save valuable time and effort. The writer also recommends that any school district investigating changes in its accounting procedures should contact its data processing service personnel early in the process. It must be determined if the equipment can perform all of the functions necessary to implement the new accounting system. It will also determine whether or not the data processing service will have to rewrite their present programs. The writer because of not having used the Illinois Program Accounting System has arrived at no conclusion as to the effectiveness of this system

Correlations by the entrainment theory of thermodynamic effects for developed cavitation in venturis and comparisons with ogive data

A semi-empirical entrainment theory was employed to correlate the measured temperature depression, Delta T, in a developed cavity for a venturi. This theory correlates Delta t in terms of the dimensionless numbers of Nusselt, Reynolds, Froude, Weber and Peclet, and dimensionless cavity length, L/D. These correlations are then compared with similar correlations for zero and quarter caliber ogives. In addition, cavitation number data for both limited and developed cavitation in venturis are presented